I IONS

Ionis Pharmaceuticals Inc

$74.79

-0.45% ($0.34)

Volume 1.79M

52W High $86.74

52W Low $23.95

Market Cap $13.70B

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What to Watch This Quarter

Based on historical data

Consensus EPS

-$0.78

Whisper EPS

-$0.78

0.3% above consensus

Last Quarter

-$1.15

Current Streak

7 Beats

Avg Surprise (4Q)

+112.06%

Next Earnings Report

Reports in 22 days

Report Date Apr 29, 2026

Whisper Spread +0.35%

Consensus Estimate

-$0.78

Official analyst average

Whisper Number

-$0.78

What traders expect

Bullish Sentiment: The whisper number is 0.3% above consensus, suggesting traders expect a strong beat. The stock may be priced for upside surprise.

Price Chart

EPS History: Consensus vs Actual

Last 11 quarters

Price Movement Around Earnings

Q4 2025 Feb 25, 2026

1-Day: -0.41%

5-Day: +1.27%

Q4 2025 Feb 18, 2026

1-Day: +1.13%

5-Day: +2.89%

Q3 2025 Oct 29, 2025

1-Day: +3.19%

5-Day: +2.46%

Q2 2025 Jul 30, 2025

1-Day: -0.90%

5-Day: +0.18%

Revenue & Financial Performance

Revenue Whisper

$235.0M

TWN Proprietary Estimate

Last Quarter Revenue

$203.0M

-10.4% YoY

Gross Margin

96.1%

Net Margin: -112.8%

Quarter	Revenue	YoY Growth	Gross Margin	Op Margin	Net Income
Q4'25	$203.0M	-10.4%	96.1%	-105.9%	-$229.0M
Q3'25	$156.7M	+17.1%	98.5%	-102.2%	-$128.6M
Q2'25	$452.0M	+100.7%	99.1%	30.9%	$123.6M
Q1'25	$131.6M	+10.1%	98.9%	-111.6%	-$146.9M
Q4'24	$226.6M	+89.6%	98.3%	-48.9%	-$104.3M
Q3'24	$133.8M	-7.2%	99.2%	-111.1%	-$140.5M
Q2'24	$225.3M	+19.6%	98.2%	-29.3%	-$66.3M
Q1'24	$119.5M	-8.5%	98.2%	-125.1%	-$142.8M

Historical Earnings

Last 12 quarters

Quarter	Date	Consensus	Whisper	Actual EPS	Surprise %	Result
Q4 2025	Feb 25, 2026	-$1.33	-$1.22	-$1.15	+13.68%	Beat
Q4 2025	Feb 18, 2026	-$1.24	-$1.24	--	--	--
Q3 2025	Oct 29, 2025	-$1.22	-$1.22	-$0.80	+34.43%	Beat
Q2 2025	Jul 30, 2025	-$0.24	-$0.24	$0.70	--	Beat
Q1 2025	May 5, 2025	-$1.01	-$1.01	-$0.92	+8.47%	Beat
Q4 2024	Feb 19, 2025	-$0.84	-$0.84	-$0.43	+49.03%	Beat
Q3 2024	Nov 6, 2024	-$1.16	-$1.16	-$0.95	+18.10%	Beat
Q2 2024	Aug 1, 2024	-$0.92	-$0.92	-$0.45	+51.09%	Beat
Q1 2024	May 7, 2024	-$1.05	-$1.05	-$0.98	+6.67%	Beat
Q4 2023	Feb 21, 2024	-$0.83	-$0.83	-$0.06	+92.77%	Beat
Q3 2023	Nov 2, 2023	-$1.04	-$1.04	-$1.03	+0.96%	Beat
Q2 2023	Aug 9, 2023	-$0.90	-$0.90	-$0.60	+33.33%	Beat